YAP1 and malignant colon neoplasm: To study the effects of our compounds in colorectal cancer cells, in which YAP plays a crucial role in the aggressiveness and metastasis [74], we first identified the protein expression profiles of YAP and its phosphorylated form at Ser127 residue, in a panel of colon cancer cell lines (SW116 and HCA46 sensitive to Fluorouracil (5FU), LoVo, Caco2, HT29 and HCT116 less sensitive to 5FU) (Figure 7A).