To study the effects of our compounds in colorectal cancer cells, in which YAP plays a crucial role in the aggressiveness and metastasis [74], we first identified the protein expression profiles of YAP and its phosphorylated form at Ser127 residue, in a panel of colon cancer cell lines (SW116 and HCA46 sensitive to Fluorouracil (5FU), LoVo, Caco2, HT29 and HCT116 less sensitive to 5FU) (Figure 7A). This evidence concerns the gene YAP1 and colonic neoplasm.