By migrating to the tumor, MDSC elevates Arg1 and iNOS, downregulating ROS production, upregulating PD-L1 on MDSC surface, and producing CCL4 and CCL5 chemokines to attract T-regs, strongly suppressing the activity of CTLs and NK cells in the tumor microenvironment [182,183]. Here, CCL4 is linked to neoplasm.