The presence of anti-inflammatory cytokines such as IL-4 and IL-10 prevented apoptosis and destruction of pancreatic cells in a case of type I diabetes mellitus influenced by inflammatory cytokines such as IFN-γ, TNF-β and IL-1b [146], and IL-10 suppressed an inflammation secondary to transplant arteriosclerosis [147]. This evidence concerns the gene IL10 and type 1 diabetes mellitus.