In the present study, we applied kinetic-based modeling to estimate the long-term chemical stability of SAR441255, a peptidic unimolecular glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG) receptor triagonist for the treatment of diabetes and obesity [41]. The gene discussed is GIP; the disease is obesity due to melanocortin 4 receptor deficiency.