The PI3K/Akt signaling pathway activates the expressions of receptor activator of nuclear factor kappa-B ligand, parathyroid hormone related protein, and bone morphogenetic protein-2 partly through nuclear factor kappa B (NF-κB); hence, it plays a crucial role in the process of prostate cancer metastasis to bone [31]. This evidence concerns the gene PTHLH and Familial prostate cancer.