TFRC and cancer: The authors synthesized a “dual-targeting” nanomedicine made of a cationic liposome (1,2-dioleoyl-3-trimethylammonium propane—DOTAP and dioleolylphosphatidyl ethanolamine—DOPE) encapsulating TMZ, decorated with anti-transferrin receptor single-chain antibody fragments (TfRscFv), which both favored crossing the BBB and targeted cancer cells.