TMZ-liposomes composed of EPC:Chol:DSPE-PEG2000-Maleimide:DSPE-PEG2000 were specifically tailored for CD133+/ALDH1+glioblastoma stem cell uptake and BBB crossing through maleimide crosslinking to the thiolated forms of an anti-CD133 monoclonal antibody and angiopep-2 (An2), a LRP1 ligand which exhibits a better BBB penetration capability than other proteins, including transferrin [117]. The gene discussed is PROM1; the disease is glioblastoma.