To reverse cancer cell thermoresistance, HSP inhibitors, such as small interfering ribonucleic acid gene [23], 17-allylamino-17-demethoxygeldanamycin [24], gambogic acid [25], 2-phenylethynesulfonamide [26], etc., are incorporated into PTAs and delivered to cancer cells. This evidence concerns the gene HSP90B2P and cancer.