Other angiogenesis-related factors with an impact on prostate cancer are miR-185, since it inhibits prostate cancer angiogenesis induced by the nodal/ALK4 pathway and suppress in vivo tumor development [68], and SOCS6, which operates as a tumor suppressor by promoting apoptosis and blocking angiogenesis in prostate cancer [69]. This evidence concerns the gene SOCS6 and Familial prostate cancer.