In this latter case, the photoimmunonanocongiugates (PINs), built via careful modulation of antibody orientation and surface density grafting, demonstrated a high selectivity for cancer cells, with up to 100-fold preferential binding and up to 30-fold improvements in EGFR-specific photokilling of EGFR-overexpressing cells in 2D cellular cultures [178]. The gene discussed is EGFR; the disease is cancer.