Deoxyhypusine synthase (DHS) is an enzyme responsiblefor the post-translational hypusination of the eukaryotic initiationfactor 5A (eIF5A) that controls cell proliferation and has been linkedto cancer.64 The involvement in pathogenesistogether with the high specificity and functional relevance of thehypusination reaction have made this system an important and promisingtherapeutic target, stimulating the design and development of inhibitorsable to target the hypusination process, including the N1-guanyl-1,7-diaminoheptane (GC7). This evidence concerns the gene EIF5A and cancer.