After this process, we identified the melanocyte genes that were most enriched (average logFC in expression > 0.4) (Figure 2C, and Supplementary Table 3 and Figure 3A), which included MLANA,19SOX9,20ErbB3,21 and IGF1R22,23; this pattern is reminiscent of melanoma cells undergoing epithelial-mesenchymal transition,20,24–26 which can play key roles in tumor progression (Figure 2D). Here, MLANA is linked to neoplasm.