Similar results were found for the HR+, HER2+ subtype in which both tumor size ≥5 cm (compared with tumor size <1 cm; hazard ratio, 5.38; 95% CI, 3.33, 8.70; p<0.0001) and ≥4 positive ipsilateral axillary nodes (compared with node negative; hazard ratio, 3.74; 95% CI, 2.57, 5.44; p<0.0001) were significantly associated with mortality (Fig 4A). The gene discussed is ERBB2; the disease is neoplasm.