In previous studies, we have shown the beneficial effects of CSD treatment in multiple mouse models: heart failure (HF) induced by either transverse aortic constriction or angiotensin II (AngII) infusion [21, 22]; kidney fibrosis induced by AngII [21]; bleomycin-induced lung and skin fibrosis [12, 13, 15, 16, 23]; and aging-associated fibrosis of the heart, kidney, and brain [24]. The gene discussed is AGT; the disease is heart failure.