On multivariable analysis of laboratory blood findings, the serum level of IL-17 (HR 1.07 (1.001–1.14), P = 0.046) and PAI-1 (HR 0.82 (0.69–0.98), P = 0.026) were found to be the independent prognostic factor for COVID-19 related death. The gene discussed is SERPINE1; the disease is COVID-19.