Fig 2 (panels C and D) shows the KaplanMeier plots of cumulative long-term survival according to PHF and NT-proBNP>960 ng/L. The final Cox regression analysis showed that long-term mortality was associated with diabetes with insulin or oral treatment, preoperative NT-proBNP>960 ng/L, renal dysfunction, and age, whereas female sex appeared to be protective (Table 6). This evidence concerns the gene INS and diabetes mellitus.