For instance, this included a genetically predicted adverse effect for the HMGCR score with T2D risk (OR = 1.64, 95% CI = 1.22 to 2.20, P = 0.001), whereas a protective effect was found for the LPL score (OR = 0.73, 95% CI = 0.66 to 0.80, P = 6.05 × 10−10). This evidence concerns the gene LPL and type 2 diabetes mellitus.