ESX1 and Alzheimer disease: In addition to genes identified by previous GWAS (SCARA3, GEMIN7, TSC22D4, TAF6, CPSF2), additional RBP genes, involved in multiple stages of the RNA life cycle, were found in our AD disease module (ZC3HAV1, DNAJC2, SYMPK, C8orf34, CPSF3, HEXIM2, HOXA5, ESX1, HOXA10, SOX3, HOXB5, LARP7), majority of which were significantly down-regulated in AD (Table A in S1 Data).