Transcriptomic analysis of G6PD knockdown cells revealed the down-regulation of a number of genes implicated in prostate cancer cell proliferation and/or invasion, including LDHA, MT2A, and REG4 and up-regulation of genes involved in motility and cell death, including EPB41L3 and DAP (Fig. 4J and fig. This evidence concerns the gene REG4 and prostate carcinoma.