We evaluated G6PD gene and protein expression in human prostate cancer cell lines and found that G6PD expression was low in benign (PNT1a) and non–bone metastatic cell lines (22RV1 and LNCaP) and raised in bone metastatic cell lines (PC3, MDA PCa 2a, and DU145) (Fig. 2, A and B, and fig. Here, G6PD is linked to Familial prostate cancer.