SMO and meningioma: Single mutations of AKT1, TRAF7, KLF4, and SMO as well as the TRAKLS mutation genotype (defined by the presence of one of the following: SMO, AKT1, KLF4,TRAF7 mutation, or a combination of AKT1/TRAF7 of KLF4/TRAF7) was shown to be associated with clinical factors and occur typically in WHO grade I meningiomas (6, 7).