As depicted in the heatmap and in the volcano plot (Fig. 6), apolipoprotein C-III (APOC3), beta-2-glycoprotein 1 (APOH), C4b-binding protein alpha chain (C4BPα), Complement C3 (CO3) and immunoglobulin kappa variable 2–30 (KV230) were significantly increased in Control individuals, while alpha-1-antichymotrypsin (AACT) isoform 1, complement component 9 (CO9), immunoglobulin heavy constant mu (IGHM) Isoform 2 and keratin, type II cytoskeletal 6A (K2C6A) were significantly increased in AD cases. This evidence concerns the gene MT-CO3 and Alzheimer disease.