It has been shown that CN gain at the PDGFRA locus can influence the relative frequency of tumor malignant cells and promote the tumor growth, whereas high expression of PDGFRA in glioblastoma can markedly improve the prognosis of patients (Motomura et al. 2012; Neftel et al. 2019). The gene discussed is PDGFRA; the disease is glioblastoma.