Moreover, we found that in most cancers, tumor-infiltrating immune cell subsets, especially the effector immune cell subsets such as Activated CD8 T cell, Effector memory CD8 T cell, Activated B cell, and Immature B cell are less abundant in the group of PDGFRA pathway CN gain (Seo et al. 2018; Han et al. 2020; Bian et al. 2021). This evidence concerns the gene CD8A and neoplasm.