Since TNAP has been identified among the top calcification-related genes overexpressed in the human trabecular meshwork [61], and as it is also expressed in pathological neofibrovascular tissues surgically excised from eyes with diabetic retinopathy [16], it would be interesting to evaluate the distribution of this enzyme in the eyes with pathological neovascularization and ectopic mineralization. Here, ALPL is linked to diabetic retinopathy.