Our findings extend results from previous studies of longer lifetime lactation duration in association with lower risks of new-onset stroke.20,22 Previous studies hypothesized that a longer lactation duration could increase women’s energy consumption, improve glucose and lipid metabolism, and therefore reduce the risk of CVDs.31,32,33 For example, participants who lactated for more than 10 months had improved insulin sensitivity and were less likely to develop impaired glucose intolerance compared with those who lactated for less than 10 months.31 Here, INS is linked to stroke disorder.