SCN1A and epilepsy: Although Scn1a+/- mice exhibit multifocal epilepsy, temperature-induced seizures have been shown to prominently emanate from the temporal lobe (Liautard et al., 2013), and focal hippocampal Nav1.1 reduction is sufficient to confer temperature-sensitive seizure susceptibility in conditional Scn1a+/- mice (Stein et al., 2019).