SCN1A and Dravet syndrome: Hence, mechanisms of seizure generation and maintenance of chronic epilepsy in DS remain unclear despite this now growing literature characterizing deficits in Scn1a+/- mice at a single cell level (Cheah et al., 2012; Dutton et al., 2013; Favero et al., 2018; Goff and Goldberg, 2019; Ogiwara et al., 2007; Tai et al., 2014).