Therefore, we next tested the intrinsic properties of DG PV-INs in Scn1a+/- mice versus wild-type littermate controls based on the involvement of these cells in DS pathogenesis as well as the fact that the GC response to PP input is known to be powerfully regulated by feedforward inhibition mediated by DG PV-INs (Ewell and Jones, 2010; Lee et al., 2016). The gene discussed is SCN1A; the disease is Dravet syndrome.