Pathogenic variants in SCN1A, which encodes the voltage-gated sodium channel α subunit Nav1.1, cause a spectrum of epilepsies including Dravet syndrome (DS) (Claes et al., 2001), the most common developmental and epileptic encephalopathy. This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.