These possibilities could be further explored using experimental manipulations to exacerbate (Dutton et al., 2017; Hawkins et al., 2017; Salgueiro-Pereira et al., 2019) or ameliorate (Hawkins et al., 2017) the epilepsy phenotype of Scn1a+/- mice; subsequent testing of the excitability of the corticohippocampal circuit could help parse the contribution of the genotype (common across cohorts) versus, for example, the effect of ongoing seizures, to disease severity. The gene discussed is SCN1A; the disease is epilepsy.