In addition, miR-449a overexpression weakened the carcinogenic effect of PEG10, while the addition of RPS2 eliminated the inhibitory effect of miR-449a overexpression on the proliferation, migration, and invasion of NB cells, indicating that PEG10 regulating RPS2 expression by targeting miR-449a in NB cells. The gene discussed is RPS2; the disease is neuroblastoma.