The aldehyde dehydrogenase(ALDH) superfamily of 19 different humanisoforms is a group of NAD(P)+-dependent enzymes that catalyzeseveral cellular processes, including detoxification of endogenousand exogenous aldehydes and biosynthesis of retinoic acid (RA), whichis a modulator of stem cell (SC) differentiation.1−3 Recent interestin ALDHs emerges from their roles linked to cancer cell proliferation,differentiation, and survival4,5 and potential as markersof tumor-initiating cells or cancer SCs (CSCs).6 This evidence concerns the gene LDHA and cancer.