NEP inactivates a wide range of peptide substrates including enkephalins, neurokinin A, substance P, bradykinin, endothelins, somatostatin, adrenomedullin, bombesin‐like peptides, glucagon, thymopentin as well as the amyloid‐β (Aβ) which accumulates in Alzheimer's disease (AD) (Nalivaeva et al., 2020). Here, KNG1 is linked to early-onset autosomal dominant Alzheimer disease.