After injury, the neuroinflammatory cascade that is considered an important mechanism of TBE promotes the rapid progression and progressive aggravation of TBE.[20] Highly expressed inflammatory factors in the damaged brain tissue [e.g., C-reactive protein (CRP) and interleukin-6 (IL-6)] are released into the blood circulation; then, the degree of nerve tissue damage and the prognosis can be judged according to the serum levels of inflammatory factors.[21] Many clinical studies have provided evidence of the anti-inflammatory effects of acupuncture. Here, IL6 is linked to tick-borne encephalitis.