Based on these studies, renal histopathological features of MCD are heterogeneous, including mesangial proliferative glomerulonephritis,[7] membranoproliferative glomerulonephritis,[8] interstitial nephritis,[9] crescentic glomerulonephritis,[10] and amyloidosis.[11] In addition to its other manifestations, IL-6 plays a key role in the pathogenesis of renal MCD. The gene discussed is IL6; the disease is membranoproliferative glomerulonephritis.