In a large multinational study only 10 out of 10.071 CF patients had CP.[5] Heterozygous carriers of CFTR-mutations (eg, parents of CF patients) have a 3- to 4-fold risk of developing CP.[24] Genetic analysis of 134 CP patients (71 alcohol related, 60 idiopathic) revealed at least 1 abnormal CFTR-allele in 18 (13,4%) individuals. Here, CFTR is linked to cystic fibrosis.