In a study of RP PBMC gene expression,[6] IL10 mRNA expression in freshly isolated PBMCs increased significantly in patients with RP compared with those in healthy individuals, consistent with previous data of high serum concentrations of IL10 in RP patients.[26] In contrast, IL10 mRNA expressions in 6-hour- and 24-hour-cultured PBMCs decreased significantly in RP patients compared with that in healthy individuals. This evidence concerns the gene IL10 and retinitis pigmentosa 1.