Recently, it was shown that SCFAs increased IL10-expressing Treg cells in the intestine and reduced inflammation in mouse disease models.[55–58] SCFAs controlled T cell differentiation through epigenetic modification.[55,57,58] Based on the data, a metagenomic analysis was conducted to assess alterations in gut microbial composition and gene function in patients with RP.[6]. Here, IL10 is linked to retinitis pigmentosa 1.