Serum concentrations of matrix metalloproteinase (MMP)-3, the expression of which was recognized in RP lesions, increased significantly in RP patients with respiratory involvement compared with those without respiratory involvement.[4] An adult-onset auto-inflammatory disease with somatic mutations of the ubiquitin activating E1 enzyme showed cell-intrinsic severe myeloid inflammation and developed auricular chondritis but not bronchial or laryngeal chondritis.[5]. Here, MMP3 is linked to retinitis pigmentosa 1.