This apparent link between the immune system and other nucleoporins, together with NUP93 expression in mononuclear cells, supports a relationship with immune function as does the detection of anti-NUP210 and -NUP62 antibodies in primary biliary cirrhosis, systemic lupus erythematosus, autoimmune myositis and rheumatic diseases [48]. This evidence concerns the gene NUP93 and rheumatic disorder.