INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, activation of VEGFB/VEGF receptor (VEGFR)-1 signalling confers protection against obesity-induced metabolic complications and AT inflammation through restoring insulin sensitivity and optimal vasculature in VAT, as well as inducing expression of Ucp1 in SAT, implying the role of angiogenesis in supporting beiging [68].