Nevertheless, higher vascular density and an increased expression of VEGFR2 have been observed in VAT compared with the subcutaneous depot, which is coupled with enhanced AT inflammation and hypoxia in participants with obesity, suggesting that angiogenesis mediated by VEGFA/VEGFR2 signalling is associated with a pathogenic visceral microenvironment [69]. The gene discussed is VEGFA; the disease is obesity due to melanocortin 4 receptor deficiency.