CDKN1B and neoplasm: Immunoblot analysis of tumor lysates revealed that, relative to single treatment, combined treatment with Ab27 and sorafenib increased the inhibition of phosphorylation of FAK and p27Kip1 and that combined treatment with Ab27 and doxorubicin increased the inhibition of the phosphorylation of FAK, p27Kip1, and STAT3 (Figure 3C).