TM4SF5 and cancer: One of the clones, Ab27, a chimeric antibody of scFv fused to the Fc domain of human immunoglobulin G1 (IgG1) (the scFv-Fc format15), reacted with recombinant TM4SF5 EC2 protein and naive TM4SF5 on the cell surface and was effective in inhibiting cancer cell invasion and proliferation.