CCL2 and cancer: It is considered that cancer cells flow into the liver through the blood and then enter the right heart to participate in systemic circulation metastasis, while lymphatic metastasis mostly considered that cancer cells enter the systemic circulation through the thoracic duct to induce distant metastasis [12]; Chen et al. found that LNMAT1 can activate CCL2 by recruiting hnRNPL to the promoter region of CCL2 and stimulate VEGF through macrophages-C secretion to promote lymphatic metastasis, considering that gastric cancer may undergo lymphatic metastasis through this pathway [13].