Interestingly, when we measured the humoral autoantigen levels, including those of anti-SSA, anti-SSB, and ANA, in NOD/Ltj mice, we found that at 12 weeks old (approximately 4 weeks after BPTES injection), BPTES failed to downregulate the levels of autoantigens related to SS development, whereas the serum levels of ANA were downregulated. The gene discussed is BTG3; the disease is synovial sarcoma.