3.4. Some Organ Failures Share Eight Upregulated m6A-RMRs between Groups including Four Writers WTAP, PCIF1, RBM15, and RBM15B; Two m6A-Dependent RNA Binding Proteins PRRC2A and HNRNPC; and Two m6A-Repelled RNA Binding Proteins IGF2BP2 and IGF2BP3; End-Stage Renal Failure (ESRF) Downregulates 85% of 26 m6A-RMRs, and Upregulation of 45% m6A-RMRs in Hemodialysis from ESRF (15%) May Be Associated with Clinical Benefits. The gene discussed is PCIF1; the disease is stage 5 chronic kidney disease.