Among 21 m6A-RMRs upregulated in three major metabolic cardiovascular disease groups, one regulator WTAP (RNA methyltransferase) was shared by three major groups; one regulator IGF2BP3 was shared by obesity and athero; three regulators FTO (demethylase), YTHDF2 (RNA binding protein), and G3BP1 were shared by obesity and type 2 diabetes; and four regulators such as PCIF1 (RNA methyltransferase), PRRC2A (m6A-dependent RNA binding protein), YTHDC2 (RNA binding protein), and HNRNPC (m6A-dependent RNA binding protein) were shared by type 2 diabetes and atherosclerotic diseases. Here, MBD2 is linked to obesity due to melanocortin 4 receptor deficiency.