When comparing three groups of acute inflammations, sepsis plus ARDS shared three upregulated m6A-RMRs such as writers WTAP, PCIF1, and reader YTHDF3 with sepsis plus shock; sepsis plus ARDS shared upregulation of one RNA binding protein IGF2BP2 with trauma, and sepsis plus shock shared one RNA binding protein IGF2BP3 with trauma. The gene discussed is IGF2BP2; the disease is Sepsis.