3.12. NF-κB Components and JAK/STAT Signaling (Except STAT1) Play Important Roles in Upregulating More Than Downregulating m6A-RMRs; and Tumor Suppressors TP53, PTEN, and APC Play Significant Roles in Downregulating More Than Upregulating m6A-RMRs. The gene discussed is PTEN; the disease is neoplasm.