In 20 m6A-RMRs upregulated in four organ failure groups, one upregulated m6A-RMR (RBM15B, RNA methyltransferase) was shared by HF and HBV-ALF; one upregulated m6A-RMR (PRRC2A) was shared by HF and ESRF; two upregulated m6A-RMRs (IGF2BP2 and IGF2BP3, RNA binding proteins) were shared by HBV-ALF and ESRF; and four m6A-RMRs including WTAP (RNA methyltransferase), RBM15 (RNA methyltransferase), PCIF1 (RNA methyltransferase), and HNRNPC (m6A-dependent RNA binding protein) were shared by HBV-ALF and hemodialysis. The gene discussed is IGF2BP3; the disease is hydrops fetalis.