Based on the TCGA analysis, as well as the databases published by Ma, Radvanyi, Zhao, Curtis, Richardson, Turashvil, Final, and Karnoub, we found that SPARC expression was lower in breast tissues than in invasive or ductal breast carcinoma, invasive lobular, ductal or mixed breast carcinoma, and breast phyllodes tumors. This evidence concerns the gene SPARC and breast ductal adenocarcinoma.