Thus, to elucidate the mechanism of YHPG-induced anti-influenza viral activity, this study observed the in vitro antiviral effect of YHPG in MDCK cells by examining the levels of interferon-β (INF-β) and interleukin-6 (IL-6), as well as the expression levels of target genes of TLR7, MyD88, TRAF6, JNK, p38 MAPK, and p65 NF-κB in MDCK cells infected with influenza virus. Here, IL6 is linked to influenza.