We also identified ITGA5 (target gene of miR-28-x, miR-411-y, ssc-miR-1285), ITGA6, and ITGAL (target gene of ssc-miR-326, ssc-miR-1, ssc-miR-9860-5p) as being significantly differentially expressed (DE) between the normoxic and hypoxic groups, and these are downstream genes related to the ECM, proteoglycans in cancer and focal adhesion pathways. The gene discussed is ITGAL; the disease is cancer.