SOAT1 and neuropathy: Tofacitinib was prescribed to patients with autoinflammatory diseases in the following cases: i) patient has a genetically confirmed interferonopathy or disease likely mediated by STAT-pathway; ii) patient has clinical features of interferonopathy without genetic confirmation (early disease onset, recurrent fever, skin rash, lipoatrophy, neuropathy); iii) previous treatment with other biologics failed, and a literature search suggested the possibility of successful use of JAK-inhibitors.