An AST/ALT ratio > 1.44 was an independent prognostic factor for poor cancer-specific survival and OS in patients with Oral and oropharyngeal cancer (Knittelfelder et al., 2020), De Ritis emerged as a valid prognostic marker for disease-free survival (DFS) in stage 2 and stage 3 non-metastatic colorectal cancer patients (Scheipner et al., 2021). Here, GPT is linked to metastatic colorectal cancer.