Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1)/AML1-ETO belongs to the core-binding factor (CBF) category of leukemia, which constitutes a distinct entity in the World Health Organization 2016 classification and comprises AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB-MYH11 (1). Here, CBFB is linked to acute myeloid leukemia.