However, studies on IL-21-stimulated EBV-positive DLBCL cells showed that IL-21 could upregulate the phosphorylation of host MYC, AP-1, and STAT3, as well as the expression of viral LMP-1 protein, thereby promoting the proliferation of DLBCL cells (91). The gene discussed is STAT3; the disease is diffuse large B-cell lymphoma.