Compared with healthy controls, breast cancer patients receiving chemotherapy had slower treatment speed and poorer executive function, while apolipoprotein E (APOE) and COMT gene polymorphisms were associated with cognitive impairment (52).Our previous research findings indicated that COMT (rs165599) was a risk-related genetic factor influencing CRCI in TNBC patients (23). The gene discussed is COMT; the disease is breast carcinoma.