In resistant ALK+ ALCL cell lines, autocrine IL-10/IL-10RA signaling activated tyrosine kinase (TYK)2/Janus kinase (JAK)1 signaling instead of the ALK–STAT3 pathway to activate STAT3, which stimulated the expression of IL-10, IL-10RA, and IL-10RB. This evidence concerns the gene ALK and anaplastic large cell lymphoma.