ALK and anaplastic large cell lymphoma: T308 and S473 phosphorylation by phosphatidylinositol-dependent protein kinase (PDK)1 and PDK2 activates AKT (38–40), mammalian target of rapamycin (mTOR) is then phosphorylated and activated by AKT to promote the survival and proliferation of ALK+ ALCL cells (41) (Figure 1).