The expression level of miR-7-5P was found to be downregulated in ALK+ ALCL by the application of crizotinib; it was later shown that miR-7-5P directly targets the 3′ untranslated region of RAF1 transcript, thereby negatively regulating RAF1 expression and reducing the inhibitory phosphorylation of Unc-51–like autophagy-activating kinase (ULK)1 (S757) to promote autophagy. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.