As expected, Utt-B induced a strong enhancement in PARP cleavage in Beclin1-silenced HepG2 cells, compared to the control HepG2 cells (Figure 3K) underscoring that autophagy induced by Utt-B is pro-survival in nature and inhibition of this autophagy could be utilized as a strategy to enhance the anti-tumor efficacy of Utt-B. This evidence concerns the gene BECN1 and neoplasm.