An analysis of the published CRC WES data has enabled a more complete map of CRC mutations to be produced, which indicated that high-frequency mutations such as KRAS G12D, KRAS G12V, PIK3CA E545K, PIK3CA H1047R, and BMPR2 N583Tfs ∗ 44 can combine with HLA and be presented [68]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.