The survival outcomes of advanced MM have dramatically improved with the discovery of novel targeted therapies like BRAF tyrosine kinase inhibitors (TKIs) (like – vemurafenib, dabrafenib) [9, 10] and immune checkpoint inhibitors (ICIs) (nivolumab, pembrolizumab, ipilimumab) [11–13] and established as the standard of care. The gene discussed is BRAF; the disease is Miyoshi myopathy.