PLOD1 and Anxiety: The CRF-positive neurons in the BNST (BNSTCRF+) also receive projections from DRN5-HT+ neurons via 5-HT2C receptors, and a study showed that stimulating the DRN5-HT+-BNSTCRF+ circuit results in enhanced anxiety-like behaviors by inhibiting the anxiolytic ventral BNST- (vBNST-) LH and vBNST-VTA circuits [84].